The setup just requires the installation of an addon and some knowledge about your server. Thanks to Zendesk's ExQuilla Thunderbird addon, you can connect Thunderbird to your Exchange 2007 or 2010 server through Exchange Web Services (EWS).
The ability to connect the Thunderbird email client to an Exchange server is finally possible. This option is fine for some businesses, but for the ones that want an actual email client, it's been a challenge. The problem many smaller businesses have with this is that, without Outlook, the only option is Exchange Webmail. Microsoft Exchange is one of the most widely used email servers in the business world.